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अस्थमा, सीओपीडी, निमोनिया और अन्य सामान्य श्वसन समस्याएं- इनसे कैसे निपटें – टाइम्स नाउ
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SGLT2 अवरोधक मधुमेह के रोगियों को गाउट से बचा सकते हैं – विशेष चिकित्सा संवाद

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SGLT2 inhibitors might protect diabetes patients from gout

USA: Hyperuricemia, known to cause gout, is common in patients with type 2 diabetes (T2D). Now, a recent study has found that prescribing a sodium-glucose cotransporter-2 (SGLT2) inhibitor to T2D patients might protect them from gout.

According to the study, published in the Annals of Internal Medicine, T2D patients prescribed an SGLT2 inhibitor had a lower risk of gout compared to those prescribed a glucagon-like peptide-1 (GLP1) agonist.

Hyperuricemia, excess of uric acid in the blood, is common in type 2 diabetes patients and is known to cause gout. Exercise and diet can prevent gout but many patients require long-term pharmacologic therapy. SGLT2 inhibitors are known to prevent glucose reabsorption and lower the levels of serum uric acid.

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Michael Fralick, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston, MA, and colleagues conducted this population-based new-user cohort study to compare the rate of gout between adults prescribed an SGLT2 inhibitor and those prescribed a glucagon-like peptide-1 (GLP1) receptor, an agonist.

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Read Also: SGLT2 inhibitor canagliflozin reduces gout flares in type 2 diabetes: CANVAS Program

For the purpose, the researchers studied a U.S. nationwide commercial insurance database from March 2013 to December 2017. The study involved 295 907 adults with type 2 diabetes mellitus who have newly prescribed an SGLT2 inhibitor or a GLP1 agonist. People were excluded if they had a history of gout or had received gout-specific treatment previously.

The primary outcome was a new diagnosis of gout.

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The researchers found that the gout incidence rate was lower among patients prescribed an SGLT2 inhibitor (4.9 events per 1000 person-years) than those prescribed a GLP1 agonist (7.8 events per 1000 person-years), with an HR of 0.64.

Read Also: Beyond blood sugar control, SGLT2 inhibitors reduce kidney complications: Lancet

“Future studies are necessary to confirm the findings,” concluded the authors.

The study, “Assessing the Risk for Gout With Sodium–Glucose Cotransporter-2 Inhibitors in Patients With Type 2 DiabetesA Population-Based Cohort Study,” is published in the journal Annals of Internal Medicine.

DOI: 10.7326/M19-2610

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Source: Annals of Internal Medicine

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